Educational Tool Only: This criteria engine is for educational purposes and does not provide a diagnosis. Meeting criteria here does not confirm a condition. A negative screen does not rule out medical conditions. Always consult a healthcare provider for proper evaluation and diagnosis.

Diagnostic Criteria Engine

Apply multiple diagnostic criteria frameworks for complex conditions

ME/CFS Criteria (ICD-10: G93.3)

Based on 2015 IOM/NAM criteria - requires substantial activity reduction >6 months (adults) or >3 months (children)

Substantial reduction in ability to engage in pre-illness activity levels, lasting >6 months in adults

Profound fatigue with new/definite onset (not lifelong), not from excessive exertion, not substantially relieved by rest

Post-exertional malaise (PEM): worsening of symptoms after physical/cognitive/emotional effort, often delayed onset and prolonged recovery

Unrefreshing sleep

EITHER cognitive impairment (slowed processing, memory problems, attention deficits) OR orthostatic intolerance (symptoms worsen on standing)

Symptoms NOT fully explained by other medical/psychiatric conditions (comorbidities may be present)

Long COVID Criteria (WHO 2021)

Post-COVID condition with symptoms starting within 3 months of infection, persisting ≥2 months

History of confirmed or probable SARS-CoV-2 infection

Symptoms start within 3 months of infection onset

Symptoms persist for at least 2 months

Common symptoms: fatigue, dyspnea, cognitive dysfunction, chest pain, palpitations, post-exertional symptom exacerbation

Symptoms may be new after recovery or persist from initial illness; may fluctuate or recur

Cannot be explained by alternative diagnosis (after appropriate testing)

POTS Criteria

Sustained HR increase ≥30 bpm (adults) or ≥40 bpm (12-19 years) within 10 minutes of standing, lasting ≥3 months

Sustained heart rate increase ≥30 bpm in adults (≥40 bpm ages 12-19) within 10 minutes of standing

Often absolute orthostatic tachycardia >120 bpm when standing

NO orthostatic hypotension (SBP drop <20 mmHg, DBP drop <10 mmHg)

Chronic orthostatic intolerance symptoms ≥3 months (lightheadedness, palpitations, fatigue, cognitive difficulties)

Symptoms relieved by recumbence

Not better explained by other causes (dehydration, medications, cardiac disease, adrenal insufficiency)

Criteria Progress

ME/CFS0/6

Long COVID0/6

POTS0/6

Reference Guidelines

ME/CFS

Canadian Consensus Criteria (2003)

IOM Report (2015)

Long COVID

WHO Definition (2021)

NICE Guidelines NG206

POTS

American Autonomic Society