NICE NG206 Diagnostic Criteria Engine

Apply NICE NG206 diagnostic criteria for ME/CFS (3-month timeline)

ME/CFS Criteria (NICE NG206)

NICE NG206: Diagnose ME/CFS if ALL symptoms present for 3 months and NOT explained by another condition

Debilitating fatigue worsened by activity, not caused by excessive exertion, not significantly relieved by rest

Post-exertional malaise: worsening often delayed by hours/days, disproportionate to activity, prolonged recovery

Unrefreshing sleep or sleep disturbance (exhausted/flu-like on waking, broken sleep, altered pattern)

Cognitive difficulties (brain fog, problems finding words/numbers, difficulty speaking, memory/concentration issues)

Symptoms have persisted for 3 months

Significant reduction in ability to engage in occupational, educational, social or personal activities from pre-illness levels

Symptoms are NOT explained by another condition (after appropriate investigations)

Long COVID Criteria (WHO/NASEM 2024)

Post-acute sequelae of SARS-CoV-2 infection with persistent multi-system symptoms

Confirmed or probable SARS-CoV-2 infection

Symptoms persist ≥3 months from acute illness

Multi-system symptoms affecting daily functioning

Symptoms not explained by alternative diagnosis

POTS Criteria (ESC 2018/AAS-EFAS 2021)

Heart rate increase ≥30 bpm within 10 minutes of standing, with symptoms but without orthostatic hypotension

Heart rate increase ≥30 bpm within 10 minutes of standing (≥40 bpm for ages 12-19)

Sustained heart rate ≥120 bpm while standing OR sustained tachycardia

Orthostatic symptoms: dizziness, palpitations, fatigue, brain fog, or syncope

Chronic symptoms present for ≥3 months

Absence of orthostatic hypotension (SBP drop <20 mmHg or DBP drop <10 mmHg)

Educational Tool Only

This is an educational tool for healthcare learning. NOT a medical device. Never use for patient care or diagnosis. Always consult medical professionals.

Created by

Willem Gielen MD

InvisibleDx.com

View Source Code

Based on Medical Guidelines

CDC ME/CFS Guidelines D-A-CH ME/CFS Consensus (2024)WHO Long COVID Definition ESC POTS Guidelines

InvisibleDx • Educational Tool • v1.0